Poster Presentation 2014 International Biophysics Congress

Determination of relations between hemarehology, lipid peroxidation, antioxidant defence and trace elements in COPD (#251)

Mehmet Can Akyolcu 1 , Devrim Saribal
  1. Biophysics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

Most frequently observed symptoms of COPD (Chronic obstructive pulmonary disease) are obstruction of inspiration and expiration.

Increased concentration of free radicals and ROS (reactive oxygen species) is observed against inflammatory reaction depending to the air way obstruction due to COPD. Oxidative stress has important role in pathogenesis of COPD. By reacting of the oxidants with proteins, lipids and nucleic acids lead to cell dysfunction or cell death.

In present study oxidative stress dependent lipid peroxidation due to the impaired circulatory hemadynamic, SOD (Superoxide Dismutase), catalase enzyme activities  and MDA (malondialdehyde) levels were determined. The role of the trace elements in enzyme activities and changes in hemarehology and relation of them with defense system molecules were also searched.  

While, 25 male COPD patients  were taken as a ‘’Patient Group ‘’ , another healthy 25 male taken as ‘’Control Group’’

As a lipid peroxidation product MDA was found to be statistically higher in plasma and red blood cell but GSH , SOD and Catalase enzyme activity lower in rbc of patient group than that of controls. (p < 0, 01). While decreased Fe(iron) and Zn  but increased Cu concentrations were determined in patient samples than that of control group values (p<0,05), (p<0,01). There was no statistically significant difference determined in neither  plasma nor blood viscosities.

As a result of the present study it may be concluded that: COPD leads to the lipid peroxidation in rbc membrane but as an opposite result of expectations no reaction can be performed in the name of defense mechanism of the organism and determined unstable concentrations of the Fe, Cu and Zn those can interact with defense system molecules, may be the sign of the altered physical environmental changes which can effect the attitude of the proteins in organism,  originated from COPD.

 MDA, SOD, catalase, COPD