Dr. Ludtke received his bachelor’s degree in Physics from Caltech in 1990, and his PhD in Physics (Membrane Biophysics) from Rice University in 1996. He is now a Professor of Biochemistry and Molecular Biology at Baylor College of Medicine in Houston, TX. He also codirects both the National Center for Macromolecular Imaging, an NIH sponsored biotechnology resource center focusing on CryoEM and related techniques, and the Computational and Integrative Biomedical Research Center (CIBR). His group has been developing the widely-used EMAN image processing software suite for the last 18 years. His research has spanned a wide range of structural biology projects from chaperonins to ion channels to basic membrane biophysics. In the mid 2000’s, in collaboration with several other groups, his group published some of the first CryoEM structures to surpass 5 Å resolution, presaging recent technological developments, which have now made high resolution CryoEM structures commonplace. Recent developments include new approaches for subtomogram averaging and application of deep learning techniques to segmentation of cellular tomograms, both related to studying macromolecular structure within the cell. His lab is also actively working on new methods to study population dynamics via CryoEM.
Abstracts this author is presenting: