Poster Presentation 2014 International Biophysics Congress

The water pore formation in the oxidized lipid bilayer  (#614)

Jirasak Wong-ekkabut 1 , Phansiri Boonnoy 1 , Viwan Jarerattanachart 1
  1. Department of Physics, Faculty of Science, Kasetsart University, Bangkok, Thailand

The oxidized lipids have affected on the lipid bilayer properties, especially the increase of water permeability and the introduction of water pore formation across lipid bilayer. The pore formation process on oxidized bilayer had been investigated by using MD simulation. The binary mixture of lipid bilayers between 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) and its peroxide/aldehyde products, were performed at 50%, 75% and 100% oxidized lipid concentrations . In addition, the asymmetrical short chain lipid, namely 1-palmitoyl-2-decanoyl-sn-glycero-3-phosphatidylcholine (PDPC), had been used to compare the effect of polar groups in the oxidized lipid tail on lipid bilayer. The results showed that aldehyde lipid had more potential to induce the water pore across the bilayer than peroxide lipid because of the decrease of bilayer thickness and the widely distribution of oxygen in lipid interior. Furthermore, the preferred secondary structures of oxidized lipid will be proposed in this study.