Recently, S. aureus, which has penicillin, ampicillin and tetracycline resistant, is increasing but it is known that S. aureus sensitively reacts to antibiotics[i]. The object of this study is to get effective antibacterial activity by using ampicillin among many antibiotics and medium molecular weight chitosan (MMWC, 6.6kDa) which is known as having antibacterial activity on antibiotic-resistant S. aureus. As results of this study, S. aureus growth was shown as 15%, 17% decrease respectively when using ampicillin(1.25㎍/㎖) and MMWC(50㎍/㎖) apart. The mixture, which is combined with ampicillin(1.25㎍/㎖) and MMWC(50㎍/㎖), surpress S. aureus growth as 47%. Therefore these results show that mixed with ampicillin and MMWC has synergic effect of S. aureus growth, and these suggest us to review antibacterial activity of chitosan material. Further study, we will investigate about synergic effect of different antibiotics and MMWC.
[i] Franklin D.Lowy, antimicrobial resistance: the example of Staphylococcus aureus, 2003, 111:1265-1273
Acknowledgement
This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(2010-0023538)