Amino acid transporters regulate intracellular amino acid levels, and therefore changes in transporter expression or activity may affect cell growth and survival.
Among the amino acid transport systems, system L is a major route for providing cells with large neutral amino acids. Moreover, L-type amino acid transporters are highly expressed at different stages during the development and progression of prostate cancer, suggesting these proteins are suitable targets for therapeutic drug design [1-3].
In order to provide more details about these essential membrane proteins and to elucidate their role in prostate cancer, we are currently using a range of structural and functional approaches.
These studies will facilitate the design of specific inhibitors to modulate leucine uptake during the different stages of prostate cancer.