Abstract: Objective: Abnormal Savda Munziq (ASMq), A formulation of Uighur medicine has been used orally for the treatment of neuron diseases such as depression, Alzheimer’s disease, memory dysfunction, seizures and so forth. Previously, we reported the effects of ASMq on the behavioral, neurochemical and neuroendocrine effects of Abnormal Savda Munziq in the Chronic Stress Mice.Methods: The present study was carried out to evaluate the in ameliorating memory impairment in the Tg-APPswe/PS1dE9 mouse and to explore the underlying molecular mechanism. This study was undertaken to evaluate beneficial effects of a ASMq in the neurodegenerative diseases such as Alzheimer’s disease (AD). ASMq extract (2, 4, 8g/kg) was administrated to the mice during a period of 6 months(from 3 to 9 months old). The transgenic mice were administrated Donepezil (100mg/kg) as a positive control. Spatial memory was assessed by Morris Water Maze. Acetylcholine (Ach) levels, acetylcholineesterase (AchE) activity, Choline acetyltransferase (ChAT) activity, monoamine oxidase (MOA), oxidative stress markers (SOD, GSH-Px, T-AOC, CAT and MDA) and nitricoxide (NO) concentration were assessed in the hippocampus.Result & Conclusion: Results showed that ASMq treatment for six months decreased escape latency and swimming distance of mice from the third day in maze tests, and increased percent time in the target quadrant, along with increase SOD, GSH-Px, T-AOC, CAT and decreased NO and MDA concentration, show a free radical scavenging property. ASMq increased Ach conceteration and ChAT activity, MOA and AChE level was decreased to improve the cognition by enhancing cholinergic transmission. These results indicate that the protective effects of ASMq against the impairment of learning and memory in hippocampus of mouse model of Alzheimer’s disease may be associated with improves cholinergic system, alleviates oxidative stress and mediated monamine neurotransmitter.
This work was supported by National Nature Science of China（81260565）